Drug efficacy assessment
After drug treatment , accurate tracking of viral load changes in the body of patients with infectious diseases is the key to drug efficacy assessment. Digital PCR technology is used for functional cure confirmation of infectious disease treatment due to the reliability and high accuracy of its test results.
Drug resistance locus monitoring
The detection of oncogene mutation locus by digital PCR with higher sensitivity means that drug resistance locus can be detected earlier in the clinic. Early (trace) detection of rare drug resistance variants may have potential impact on clinical studies and patient management, reducing the number of ineffective drugs taken and early switching to alternative drugs.
Detection of residual DNA in protein-based drugs
Many protein-based drugs (e.g., insulin) are produced in yeast cells. Impurities from host cells pose a safety concern, and regulatory agencies have specified acceptable levels of impurities in protein drugs. Digital PCR technology has been successfully applied to the detection of yeast residues in drug development with excellent sensitivity and accuracy.
Detection of microbial residues in attenuated vaccines
In some vaccines, the viral dose is extremely low, making it difficult to detect viral contamination by conventional detection techniques, leading to huge economic losses worldwide. Detection using digital PCR technology can detect viral contamination in vaccines more sensitively and accurately.
Authentication of Chinese herbal medicines and detection of epidemic diseases in Chinese medicine
Authentication of Chinese herbal medicines is the primary link in the quality control of Chinese medicines. The combination of digital PCR technology and traditional methods allows for more accurate and rapid identification and post-checking of the quality of Chinese herbal medicines, as well as prevention and surveillance of epidemics in Chinese herbal medicines.